Rejuran vs. Juvelook: Which Skin Booster Is Right for You? A Comparison by Ingredients, Depth, and Timing

When you start researching skin boosters, the two options people most often weigh side by side are Rejuran and Juvelook. Both are injectable treatments that deliver ingredients directly into the skin, so they may look similar. However, the ingredients they use, the depth of injection, and the time it takes to see results all differ. Rather than declaring one better than the other, this article breaks down how the two treatments differ in three areas, based on the treatment guide from 1mm Plastic Surgery.

Dark navy background with the title ‘Rejuran vs. Juvelook: Organized by Ingredients, Depth, and Timing’ at the top and two skin cross-section illustrations side by side below. On the left, ‘Rejuran Healer PN’ shows small droplets spreading across the upper dermis. On the right, ‘Juvelook PDLLA + HA’ shows small particles and a collagen mesh between the dermis and the fat layer. — The two treatments differ in **what is injected, where it goes, and when changes appear**. (Illustration for explanation only)

Rejuran and Juvelook — aren't they both skin boosters?

[What we often hear at the consultation desk] Which is better, Rejuran or Juvelook?
Both are injected, but is what gets injected different?
Which one should I try first for my skin?

Rejuran (Rejuran Healer) and Juvelook both inject ingredients into the skin to help the skin regenerate on its own, which is why they are grouped together as “skin boosters.” In fact, they overlap in the changes they can target, such as firmness, fine lines, skin texture, and pores.

That's why people naturally ask which one is better. But the two treatments differ clearly in three ways:

Ingredients — what is injected
Injection depth — where in the skin it is placed
Timing — when changes begin to show, and at what intervals to see them

Once you understand these three points, it becomes easier to discuss in a consultation which option fits your skin condition and schedule.

Ingredients: PN from salmon DNA, and PDLLA and hyaluronic acid

The difference between the two treatments starts with the ingredient being injected.

Skin Booster 01 / 02 · Rejuran Healer (PN · polynucleotide)

A treatment that injects PN (polynucleotide), derived from salmon DNA, to help thinned and damaged epidermis and dermis regain a healthy skin environment.

Skin Booster 02 / 02 · Juvelook (PDLLA microparticles + HA)

A collagen booster that combines PDLLA microparticles, a polymer, with hyaluronic acid. It works by encouraging the skin to produce its own collagen while the injected material gradually breaks down.

At a glance
Rejuran Healer focuses on restoring a healthy skin environment, while Juvelook focuses on promoting the skin's own collagen production. Both ingredients are gradually broken down by the body over a set period of time.

Injection depth: 1–2 mm in the dermis, and between the dermis and fat tissue

The second difference is where in the skin the product is placed.

Skin cross-section illustration. Small light-blue droplets spread across the upper dermis just beneath the epidermis, and the fibroblasts between them glow faintly. Title: ‘Rejuran Healer — PN derived from salmon DNA into the dermis.’ Next to a ruler on the left is the label ‘1–2 mm below the skin surface, injected into dermal fibroblasts.’ — Illustration for explanation only — Rejuran Healer is injected into the **dermis, 1–2 mm below the skin surface**.

Rejuran Healer needs to be injected precisely into the fibroblasts in the dermis, 1–2 mm below the skin surface, to achieve more satisfying results. Hitting the right shallow layer is the key.

Skin cross-section illustration. At the deep boundary where the dermis meets the yellow fat layer, small white particles lie in a band, and fine collagen fibers grow upward from them into a dense mesh. Title: ‘Juvelook — PDLLA microparticles + hyaluronic acid, placed deeper.’ Next to a ruler is the label ‘Between the dermis and fat tissue, promotes collagen production as it breaks down.’ — Illustration for explanation only — Juvelook is injected **between the dermis and fat tissue**, and promotes collagen production as it breaks down.

Juvelook is injected between the dermis and fat tissue in areas with loss of firmness, wrinkles, scars, or sunken volume. As the injected material breaks down, it stimulates collagen production, which is how it improves skin firmness.

Why depth matters
Even within the same treatment, injection depth is a factor that can affect results. That's why it is important to check your current skin condition first, rather than focusing on the name of the treatment.

Timing: when do changes appear, and at what intervals?

The third difference is timing. What your skin looks like right after treatment, when changes start to appear, and the recommended intervals all differ.

A two-row timeline illustration. The top row, Rejuran Healer, reads ‘Embossing right after treatment → Mostly over 60% absorbed within 10 hours → Daily activities from the next day → Repeat every 2–3 weeks.’ The bottom row, Juvelook, reads ‘Changes from day 3–4 → Most noticeable around week 4 → 3 sessions recommended at 4-week intervals → Lasts about 6 months to 1 year, individual results may vary.’ — This summarizes the content of the treatment guide page on 1mm Plastic Surgery's website, arranged in chronological order. Progress and duration of results may vary by individual.

Timeline 01 / 02 · Rejuran Healer (from the next day · every 2–3 weeks)

After treatment, a slight raised bump called embossing may form at the injection sites, but it is usually over 60% absorbed within 10 hours, so you can typically resume normal daily activities the next day. To maintain and build on the results, it's best to repeat the treatment on a regular cycle of every 2–3 weeks.

Timeline 02 / 02 · Juvelook (around week 4 · 3 sessions at 4-week intervals)

Changes begin to appear around days 3–4 after treatment, and you may notice the most significant improvement around week 4. Although you may notice a change after a single session, a total of three sessions at 4-week intervals is recommended. Results generally last about 6 months to 1 year after the first treatment. Duration can vary depending on skin condition, the number of sessions, and other factors.

When planning your schedule
For Rejuran Healer, it's helpful to plan around the embossing on the day of treatment. For Juvelook, plan around the few weeks it takes for collagen to build up.

Which one should we discuss for your skin first?

Because the two treatments overlap in the changes they can target, it's easiest to start your consultation with whatever concern bothers you most right now.

Concern	Treatment to discuss first
When skin looks thin, lacks resilience, and appears dull	Rejuran Healer
When skin has been damaged by UV exposure or external irritation	Rejuran Healer
When acne scars are a concern	Juvelook
When certain areas look sunken or lacking in volume	Juvelook
When loss of firmness, fine lines, or pores are the concern	Both — depending on skin condition

This table organizes the “Cases where treatment is needed” section from the 1mm Plastic Surgery treatment guide by concern. It is not a comparison of which is better, and the actual choice is made through a medical consultation.

Juvelook is further divided into Juvelook Skin, which focuses on skin texture, pores, and scars, and Juvelook Volume, which addresses sunken volume and deeper wrinkles. Even under the same name, the product may differ depending on which concern is being addressed.

Here's the key point
Rather than choosing based on the treatment name alone, it's better to first check whether your skin looks thin and fatigued, and whether there are areas that need filling.

Good to know before and after treatment

Organizing the four points below before your consultation will help you decide whether to proceed and when.

Whether you have a salmon or fish allergy — The PN in Rejuran Healer is derived from salmon DNA.
Whether you are pregnant or breastfeeding — If this applies to you, be sure to tell your medical team before treatment.
Whether you have any important events coming up soon — Embossing, swelling, or bruising may still be present.
The one concern that bothers you most right now — skin texture, firmness, or sunken volume.

Treatment	Post-treatment precautions
Rejuran Healer	Right after treatment, the injection sites can become infected with bacteria, so it's best to avoid swimming, saunas, and strenuous exercise for a while.
Juvelook	Skin may become dry, so it's important to moisturize well, avoid excessive irritation, and keep the treatment area clean.

Post-treatment precautions are based on the content of the treatment guide page on 1mm Plastic Surgery's website.

Please keep in mind
Since both treatments are injection procedures, swelling and bruising may occur, and recovery varies from person to person. If any discomfort lasts a long time after treatment, please check with the clinic where you were treated.

In summary, it's about the right order for your needs, not which treatment is “better”

Criteria	Rejuran Healer	Juvelook
Ingredient	PN extracted from salmon DNA	PDLLA microparticles + hyaluronic acid
Focus	Restoring the skin environment	Promoting the skin's own collagen production
Injection depth	1–2 mm into the dermis from the skin surface	Between the dermis and fat tissue
After treatment	Embossing; mostly over 60% absorbed within 10 hours	Changes from day 3–4, most noticeable around week 4
Interval	Repeated periodically every 2–3 weeks	3 sessions recommended at 4-week intervals

The two treatments, revisited through three criteria. Progress and duration of results may vary by individual.

Rejuran and Juvelook are treatments that differ in their ingredients, injection depth, and the time it takes for changes to appear. Even with the same treatment, the changes you can expect may vary depending on your skin condition.

In short
Rather than deciding on a specific treatment in advance, it's important to have your current skin condition checked through a consultation with a board-certified specialist and then decide on the treatment.

Frequently Asked Questions

Which is better, Rejuran or Juvelook?

Neither can be declared the better option. Rejuran Healer injects PN derived from salmon DNA into the dermis, 1–2 mm below the skin surface, with a focus on restoring the skin environment. Juvelook injects PDLLA microparticles and hyaluronic acid between the dermis and fat tissue, promoting the skin's own collagen production. Which treatment is right for you can vary depending on your current skin condition.

Can I return to normal daily activities right after Rejuran treatment?

Right after treatment, you'll have embossing at the injection sites, but it is usually over 60% absorbed within 10 hours, so you can typically resume normal daily activities the next day. However, since the injection sites can become infected with bacteria right after treatment, it's best to avoid swimming, saunas, and strenuous exercise for a while.

When will I start to see results from Juvelook?

Changes begin to appear around days 3–4 after treatment, and you may notice the most significant improvement around week 4. Although you may see a change after a single session, three sessions at 4-week intervals are recommended, and results generally last about 6 months to 1 year after the first treatment. Duration can vary depending on skin condition, the number of sessions, and other factors.

Can I get Rejuran if I have a salmon allergy?

The PN in Rejuran Healer is derived from salmon DNA. If you are allergic to salmon or fish, be sure to tell your medical team before treatment, and whether you proceed should be decided through a medical consultation.

Are there things to watch out for after treatment?

After Rejuran Healer treatment, the injection sites can become infected with bacteria, so it's best to avoid swimming, saunas, and strenuous exercise for a while. After Juvelook, skin may become dry, so it's important to moisturize well, avoid excessive irritation, and keep the treatment area clean.

What we do during your consultation

Through an examination by a board-certified plastic surgeon,
we help you find the treatment that suits your skin

Examination by a board-certified plastic surgeon
One-on-one personalized plan that considers your individual characteristics
Ongoing academic and research activities
Disinfection and sterilization to prevent infection

We'll consult with you on a one-on-one personalized plan that takes your individual characteristics into account.

Consultation and Booking Information

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This post was written by the operator of a medical institution to provide medical information. Treatment information is based on the Rejuran Healer and Juvelook treatment guide pages of 1mm Plastic Surgery. The skin cross-section illustrations in this article are for explanatory purposes only and are not actual patient photos or treatment results. Rejuran Healer and Juvelook are product names owned by their respective manufacturers. Whether each treatment is applicable, along with the results, recovery progress, and duration of results, may vary depending on individual skin condition, and side effects such as swelling and bruising may occur. Please consult a medical professional for details.